Postdoctoral Fellow (Schmiedel Lab)

9420 Athena Cir, La Jolla, CA 92037, USA Req #351
Thursday, March 7, 2024

Job summary:

The laboratory of Dr. Benjamin Schmiedel at the La Jolla Institute for Immunology (LJI), La Jolla, CA is looking for a talented and motivated Postdoctoral Researchers to join our efforts in the fields of genetics, immunology and single cell genomics. We are employing cutting-edge methods (single-cell RNA-seq, ATAC-seq, ChIP-seq, etc.) to better our understanding of the regulation of gene expression in human immune cells, and aim to identify novel options for diagnostics and treatment of autoimmune diseases.

 

Qualified Candidates should have:

Background in genomics, gene regulation, human immunology, mouse models. 

 

Publications to review:

  1. Schmiedel BJ, Seumois G, Samaniego-Castruita D, Cayford J, Schulten V, Chavez L, Ay F, Sette A, Peters B, Vijayanand P. 17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells. Nat Commun. 2016. PMID: 27848966.
  2. Schmiedel BJ, Singh D, Madrigal A, Valdovino-Gonzalez AG, White BM, Zapardiel-Gonzalo J, Ha B, Altay G, Greenbaum JA, McVicker G, Seumois G, Rao A, Kronenberg M, Peters B, Vijayanand P. Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression. Cell. 2018. PMID: 30449622.
  3. Seumois G, Ramirez-Suastegui C, Schmiedel BJ, Liang S, Peters B, Sette A, Vijayanand P. Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma. Sci Immunol. 2020. PMID: 32532832.
  4. Chandra V, Bhattacharyya S, Schmiedel BJ, Madrigal A, Fotsing S, Seumois G, Kronenberg M, Peters B, Ay F, Vijayanand P. Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants. Nat Genet. 2021. PMID: 33349701.
  5. Schmiedel BJ, Rocha J, Gonzalez-Colin C, Bhattacharyya S, Madrigal A, Ottensmeier CH, Ay F, Chandra V, Vijayanand P. COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types. Nat Commun. 2021. PMID: 34799557.
  6. Schmiedel BJ, Gonzalez-Colin C, Fajardo V, Rocha J, Madrigal A, Ramirez-Suastegui C, Bhattacharyya S, Simon H, Greenbaum JA, Peters B, Seumois G, Ay F, Chandra V, Vijayanand P. Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants. Sci Immunol. 2022. PMID: 35213211.

 

To apply: 

Please submit a CV & cover letter and indicate one or more potential matches to the specific projects from above. Applications without a cover letter will NOT be reviewed.

 

About LJI

The La Jolla Institute for Immunology, located in the UCSD Science Research Park, offers a collegial work environment that emphasizes collaboration, teamwork and creativity. The full-time employment at LJI includes a competitive salary, medical/dental/vision benefits, paid sick leave, and contributions to a retirement plan (403B). In 2017, LJI was ranked as one of the best places to work in San Diego by the San Diego Business Journal. The Institute hosts world-renowned faculty and over 100 postdoctoral researchers hailing from 20+ different countries. LJI is located in the Science Research Park on the campus of UC San Diego, with easy access to the San Diego life sciences community and all that the area has to offer.

 
LJI provides Equal Employment Opportunity (EEO) to all employees and applicants for employment, and prohibits discrimination and harassment of any type, regardless of race, color, religion, age, sex, national origin, marital status, disability status, genetics, medical conditions, protected veteran status, sexual orientation, gender identity or expression, reproductive health decisions, or pregnancy, or any other condition protected by state and local laws. This applies to all terms and conditions of employment, including recruitment, hiring, placing, training, promotion, compensation, benefits, transfers, educational assistance, terminations, layoffs, recalls, transfers, leaves of absences, and social and recreational programs.
 

With over 30 different countries represented, diversity is respected and celebrated at LJI. We are committed to ensuring a safe and compassionate environment that is equal, just, and fair. Science and discovery benefit from a diversity of talents, a diversity of approaches, and a diversity of perspectives. The La Jolla Institute’s Diversity, Equity, and Inclusion Initiative is designed to help us identify areas at the Institute that need improvement so we can together create an environment that is inclusive, provides equal opportunities, and opens doors that propel our research for human health. 
 
 
La Jolla Institute is committed to compensation that is externally competitive and internally equitable. We validate this commitment by conducting regular market analyses to remain competitive with organizations of similar size in the nonprofit, independent research sector. Compensation decisions consider a variety of factors including experience, education, unique skill sets, organizational need, and internal equity. 
 

Other details

  • Job Function PHD
  • Pay Type Salary
  • Min Hiring Rate $70,096.00
  • Max Hiring Rate $76,024.00
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  • 9420 Athena Cir, La Jolla, CA 92037, USA